Ever since I moved to Spain, perhaps due to changes in my daily routine and diet, I’ve been struggling with persistent acne. Those red, swollen cystic pimples were particularly frustrating. After trying countless skincare products with little success, I finally headed to a pharmacy. I was surprised to find many effective over-the-counter acne treatments available. Today, I’m sharing a few I’ve personally used or researched, hoping to help others dealing with the same issue.

A Look at Popular Acne Creams from Spanish Pharmacies
Peroxiben
This was the first treatment I tried, and it’s one of the most commonly recommended entry-level Spanish acne creams by doctors here. Its main ingredient is benzoyl peroxide, which works by killing the acne-causing bacteria (Propionibacterium acnes) and helping to unclog pores. It comes in different strengths, like 2.5%, 5%, and 10%. I recommend starting with the lowest concentration and applying it only as a spot treatment on pimples—never over large areas. The downside is that it can make your skin very dry, flaky, and even a bit red, so moisturizing is crucial. This cream is especially fast-acting on red, swollen pimples with a head.
Finacea Gel
If you’re dealing with acne alongside post-inflammatory hyperpigmentation (acne marks) and uneven skin tone, Finacea Gel is definitely worth a try. Its key ingredient is 15% azelaic acid. Azelaic acid is not only anti-inflammatory and antibacterial, but it also excels at inhibiting melanin production, making it effective against both new red marks and older brown spots. It can also help with rosacea. It has a white gel texture and is generally gentler than Peroxiben, though you might experience a slight itching sensation when you first start using it; this usually subsides as your skin builds tolerance. You can apply a thin layer all over your face, but remember that sunscreen and moisturizer are still essential.
Epiduo / Epiduo Forte
This one is a heavy-hitter—a combination gel of adapalene and benzoyl peroxide. Adapalene works to unclog pores and regulate skin cell turnover, preventing pimples and blackheads at the source, while benzoyl peroxide kills bacteria and reduces inflammation. It’s a powerful duo, so the results can be impressive. However, it’s also the most irritating, so it’s not recommended for beginners. In Spain, Epiduo Forte requires a prescription, but some pharmacies may sell the standard Epiduo without one. It’s crucial to use this only at night and be very strict with sunscreen the next day, as it can make your skin extremely sensitive.
Here is a simple table to help you compare and choose:
| Cream Name | Key Ingredient | Primary Function | Gentleness |
| Peroxiben | Benzoyl Peroxide | Rapid anti-inflammatory, antibacterial | ★★☆☆☆ |
| Finacea Gel | Azelaic Acid | Anti-inflammatory, fades acne marks, evens skin tone | ★★★☆☆ |
| Epiduo | Adapalene + Benzoyl Peroxide | Comprehensive acne treatment, unclogs pores | ★☆☆☆☆ |
Don’t panic if you get acne in Spain; there are many options available at the pharmacy. However, everyone’s skin type and the cause of their acne are different, so it’s best to consult a pharmacist before starting any treatment; they can offer professional advice. Also, remember that during this kind of treatment, moisturizing and sun protection are absolutely essential. Otherwise, you might damage your skin barrier without clearing your acne, which would be counterproductive. Hope everyone can say goodbye to acne soon!